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为制备一种对氨氯地平的识别选择材料，通过交联聚合与印迹过程同步法，以改性Fe_3O4磁性纳米微粒为载体，S-氨氯地平为模板分子，乙二醇二缩甘油醚(EGDE)为交联剂制备了S-氨氯地平磁性表面分子印迹材料1MMIP-Fe3O4@SiO2-PAM。研究了磁性分子印迹材料MMIP-Fe_3O4@SiO2-PAM对氨氯地平对映体拆分的可行性。通过FTIR光谱、扫描电镜SEM、热重分析仪TGA和磁强计VSM对功能微粒进行表征，结果表明，改性Fe3O4磁性纳米微粒表面出现了印迹空穴，且磁性表面分子印迹材料MMIP-Fe_3O4@SiO2-PAM具有良好的磁性和磁响应性。此外，通过静态、动态、选择性吸附和可重用性实验评估MMIP-Fe_3O4@SiO2-PAM的手性识别与拆分性能。结果表明印迹材料对模板分子吸附量为243 mg·g-1，选择性系数为4.56；且印迹材料具有良好的解吸性能，解吸率达到99.8%，说明其具有良好的重复性。
Abstract：In order to prepare a selective material for the identification of amlodipine, modified Fe_3O4 magnetic nanoparticles were used as carrier, S-amlodipine as template molecule and ethylene glycol diglycerol ether(EGDE)as cross-linking agent, and S-amlodipine magnetic surface molecular-imprinted material MMIP-Fe_3O4@SiO2-PAM was prepared by cross-linking polymerization and imprinting process synchronization. The feasibility of amlodipine enantiomer resolution using magnetic molecular imprinted material MMIP-Fe_3O4@SiO2-PAM was studied. The functional particles were characterized by FTIR spectroscopy, SEM, TGA and VSM. The results show that imprinted holes exists on the surface of the modified Fe_3O4 magnetic nanoparticles, and the molecularly imprinted material MMIP-Fe_3O4@SiO2-PAM has good magnetic and magnetic responsiveness. In addition, the chiral recognition and separation performance of MMIP-Fe_3O4@SiO2-PAM were evaluated by static,dynamic, selective adsorption and reusability experiments. The results show that the adsorption capacity of the imprinted material is 243 mg·g-1 and the selectivity coefficient is 4.56. The imprinted material has good desorption performance with desorption rate of 99.8%, which indicates that it has good reusability.
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基本信息:
中图分类号:O631.3;TQ460.1
引用信息:
[1]李延斌,李丽荣,胡译之,等.氨氯地平磁性印迹材料的制备及其性能[J],2022,36(06):834-843.
基金信息:
国家自然科学基金(21805249)
2021-09-24
2021
2022-04-01
2022
2