关今韬,贠军贤,关怡新,姚善泾

• 1:浙江大学化学工程与生物工程学院
• 2:浙江工业大学化学工程学院绿色化学合成技术国家重点实验室培育基地

摘要(Abstract)：

以可再生资源发酵制备的光学纯苯乳酸为单体合成的聚苯乳酸,是最新研究的一种芳香族生物基聚合物新材料,具有优异的热稳定性、机械强度和紫外吸收性能,成为继聚乳酸材料之后的重要聚合物材料,在工业领域具有潜在的广阔应用前景。高纯度苯乳酸单体的制备是聚苯乳酸工业化的关键。本文从聚苯乳酸的合成、苯乳酸单体的化学与生物合成方法及下游分离纯化等方面,对其研究现状进行了综述。苯乳酸的化学合成法有多条明确的路线,但步骤繁琐,反应条件苛刻,副产物多,尚不能工业化应用;生物合成法制备苯乳酸的反应条件温和,具有很好的可持续性;用生物安全性优良的高产菌株进行生物转化及酶法合成,成为苯乳酸工业化发展的重要方向。但是,采用常规纯化方法从生物发酵液或转化液中分离纯化得到苯乳酸时,尚存在处理量较小、工艺繁琐、反应条件苛刻等局限性;近几年兴起的晶胶介质层析分离技术,可简化分离纯化步骤,其产物纯度高,过程简便,有望成为苯乳酸分离的新方法。

关键词(KeyWords)： 聚苯乳酸;苯乳酸;化学合成;生物合成;晶胶介质

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(21576240);; 浙江省自然科学基金(LZ14B060001,LY16B060011)

作者(Author): 关今韬,贠军贤,关怡新,姚善泾

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