李延斌,李丽荣,胡译之,李俊涛,唐风娣,刘振兴

• 1:肇庆医学高等专科学校基础医学部
• 2:中北大学理学院

摘要(Abstract)：

为制备一种对氨氯地平的识别选择材料，通过交联聚合与印迹过程同步法，以改性Fe_3O_4磁性纳米微粒为载体，S-氨氯地平为模板分子，乙二醇二缩甘油醚(EGDE)为交联剂制备了S-氨氯地平磁性表面分子印迹材料1MMIP-Fe3O4@SiO2-PAM。研究了磁性分子印迹材料MMIP-Fe_3O_4@SiO_2-PAM对氨氯地平对映体拆分的可行性。通过FTIR光谱、扫描电镜SEM、热重分析仪TGA和磁强计VSM对功能微粒进行表征，结果表明，改性Fe3O4磁性纳米微粒表面出现了印迹空穴，且磁性表面分子印迹材料MMIP-Fe_3O_4@SiO_2-PAM具有良好的磁性和磁响应性。此外，通过静态、动态、选择性吸附和可重用性实验评估MMIP-Fe_3O_4@SiO_2-PAM的手性识别与拆分性能。结果表明印迹材料对模板分子吸附量为243 mg·g~(-1)，选择性系数为4.56；且印迹材料具有良好的解吸性能，解吸率达到99.8%，说明其具有良好的重复性。

关键词(KeyWords)： 氨氯地平;磁性分子印迹;识别选择性;手性拆分

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(21805249)

作者(Author): 李延斌,李丽荣,胡译之,李俊涛,唐风娣,刘振兴

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