朱智博,关水,王树萍,王先犇,刘天庆,马学虎

• 1:大连理工大学 干细胞与组织工程实验室，辽宁 大连 116024

摘要(Abstract)：

引入多壁碳纳米管（multi-walled carbon nanotubes， MWCNTs）对壳聚糖/明胶/透明质酸（chitosan/gelatin/hyaluronic acid， Cs/Gel/HA）复合支架性能进行优化。采用冷冻干燥法制备出MWCNTs含量为2%、6%以及10%的Cs/Gel/HA/MWCNTs导电支架，对支架的理化性能及生物相容性进行评价。导电支架孔径为90~130 μm，孔隙率为83%~96%；扫描电镜（SEM）及接触角测量结果显示， MWCNTs增加了孔壁粗糙度，提高了支架疏水性；支架电导率随MWCNTs含量的增加而增大，最大可增加至对照组的133.82%； MWCNTs含量为6%的支架细胞活力可增加至对照组的111.07%，且具有更高的细胞粘附率。研究初步表明，制备的Cs/Gel/HA/MWCNTs导电支架具有更好的生物相容性，可进一步应用于神经组织工程研究。

关键词(KeyWords)： 多壁碳纳米管;PC12细胞;导电支架;生物相容性

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金（31670767）；中央高校基本科研业务费专项资金资助项目（DUT16QY08，DUT16RC （3）098，DUT16ZD227）。

作者(Author): 朱智博,关水,王树萍,王先犇,刘天庆,马学虎

DOI: 10.3969/j.issn.1003-9015.2017.05.017

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