魏慧龙¹,高武成¹,蒋红华²,钱超¹,陈新志¹

• 1:浙江省化工高效制造技术重点实验室，浙江大学 化学工程与生物工程学院，浙江 杭州 310027
• 2:杭州新德环保科技有限公司，浙江 建德 311604

摘要(Abstract)：

改进了BAH重要中间体3-（2-氨基-2-硫代乙基）苯甲酸甲酯的合成工艺。以苯甲酸甲酯为原料，通过氯甲基化、氰化和硫代三步反应合成3-（2-氨基-2-硫代乙基）苯甲酸甲酯。采用多聚甲醛和氯化氢作为氯甲基化试剂，通过多氯甲基副产物的循环，抑制多氯甲基化副反应，3-氯甲基苯甲酸甲酯收率可达85.3%；在水相中进行氰化反应，3-氰甲基苯甲酸甲酯收率达90.2%；以硫化氢为硫代试剂，在新型水/脒类盐酸盐的溶剂/催化剂体系中，结合滤液循环工艺，3-（2-氨基-2-硫代乙基）苯甲酸甲酯收率可达98.6%；三步反应总收率75.9%。

关键词(KeyWords)： 3-(2-氨基-2-硫代乙基)苯甲酸甲酯;苯甲酸甲酯;多氯甲基物循环;脒类盐酸盐

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金（21376213，21476194）；国家重点研发计划项目（2016YFB0301800）。

作者(Author): 魏慧龙¹,高武成¹,蒋红华²,钱超¹,陈新志¹

DOI: 10.3969/j.issn.1003-9015.2018.03.014

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