2-(4-溴甲基苯基)丙酸合成工艺的优化Optimization of synthesis processes of 2-(4-bromomethylphenyl)propionic acid
张哲明,叶向群,贡晗,阮诗想,钱超,陈新志
摘要(Abstract)：
采用气相循环与反应-萃取技术,优化了2-(4-溴甲基苯基)丙酸(BMPPA)的合成工艺,解决了现有工艺废酸量大、套用困难的问题。在气-液-液反应体系中,水相2-苯基丙酸(PPA)与多聚甲醛(PFA),氢溴酸(HBr)在溴化锌(ZnBr2)催化下反应生成的BMPPA被萃取至有机相,气相与通入的溴化氢气体强制循环,维持体系溴化氢浓度并促进传质。反应结束后,有机相冷却结晶后析出产物,结晶母液和水相套用。优化后工艺条件为ZnBr2:HBr:PFA:PPA的摩尔比为0.5:2.5:1.5:1,反应温度为80℃,时间为8h,萃取剂为正庚烷,纯化后BMPPA收率为86.7%,纯度为98%,水相和有机相套用多次,产品收率仍稳定。相比于现有工艺,该工艺的废酸量排放减少80%。
关键词(KeyWords)： 2-(4-溴甲基苯基)丙酸;2-苯基丙酸;溴甲基化;气相循环;反应-萃取
基金项目(Foundation): 浙江省低碳脂肪胺工程技术研究中心项目(2012E10033)
作者(Author): 张哲明,叶向群,贡晗,阮诗想,钱超,陈新志
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