凌慧¹,郑成^1,2,毛桃嫣¹,钟景铭¹

• 1:广州大学 化学化工学院，广东广州 510006
• 2:广州科技职业技术学院，广东 广州 510450

摘要(Abstract)：

化妆品的功效不仅在于其活性成分，也取决于载体系统。研究采用高压均质法制备包覆二苯酮-3（BP-3）和对甲氧基肉桂酸辛酯（OMC）两种紫外线吸收剂的纳米结构脂质载体（NLC），并采用扫描电镜、红外光谱、X射线衍射、差示扫描量热法等手段对其结构进行了表征分析。通过正交实验确定了最优配方为：防晒剂（OMC：BP-3=4：1）占总油相10%，总油相占配方6%，液体脂质占总脂质25%，乳化剂（A165：泊洛沙姆188：大豆卵磷脂=3：3：1）占配方4%，得到的NLC中BP-3和OMC包封率的分别为93.2%、98.8%。对紫外吸收性能和光稳定性进行测试，结果显示：包覆防晒剂的NLC比普通乳液的紫外吸收能力好，而且被包覆的防晒剂光异构化程度降低。这项研究为紫外吸收剂提供了一个合适的胶体脂质载运系统，NLC成为一个成功的光保护纳米制剂。

关键词(KeyWords)： 纳米结构脂质载体;防晒剂;包封率;表征;性能

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目（21676061）；广州市科技计划项目（201607010080）。

作者(Author): 凌慧¹,郑成^1,2,毛桃嫣¹,钟景铭¹

DOI: 10.3969/j.issn.1003-9015.2018.02.016

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