高鲁友¹,王文弘¹,彭阳峰¹,张卫东²

• 1:华东理工大学 化工学院，上海 200237
• 2:东台市 东靖医化科技有限公司，江苏 盐城 224200

摘要(Abstract)：

针对含0.015~0.03 g·mL^-1的N-羟基丁二酰亚胺（HOSU）水溶液，采用三辛胺（TOA）、正丁醇组成萃取剂，在单级液液萃取装置中通过实验筛选出最优萃取体系，考察了TOA的体积分数、两相相比、萃取温度、盐析剂等对HOSU在油水两相中分配系数的影响，并测定了该系统在25℃下的相平衡数据。红外光谱图分析结果表明TOA对HOSU的络合萃取同时存在氢键缔合和离子缔合两种形式。基于质量作用定律，建立了表达该萃取过程的相平衡模型，对25℃的萃取相平衡数据进行关联，结果表明有机相中HOSU浓度的实验值与模型计算值吻合良好。

关键词(KeyWords)： N-羟基丁二酰亚胺;三辛胺;正丁醇;萃取;络合萃取

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 高鲁友¹,王文弘¹,彭阳峰¹,张卫东²

DOI: 10.3969/j.issn.1003-9015.2017.04.002

参考文献(References)：

• [1] WU Yong-ping (吴永平), WANG Qi (王琦), SHEN Yang (沈杨), et al. A new method of synthesizing paclitaxel-octreotide conjugate (合成紫杉醇-奥曲肽偶联物的新方法)[J]. Chinese Journal of Synthetic Chemistry (合成化学), 2014, 22(6):840-842.
  [2] Zhang C, Tao F R, Cui Y Z. Properties of gelatin films cross-linked by N-hydroxysuccinimide-activated furandicarboxylic acid (NHS-FDCA)[J]. Polymer Bulletin, 2016, 73(6):1565-1580.
  [3] Kortenaar P, Dijk B G, Peeters J M, et al. Rapid and efficient method for the preparation of Fmoc-amino acids starting from 9-fluorenylmethanol[J]. International Journal of Peptide and Protein Research,1986, 27(4):398-400.
  [4] Milton R C D, Becker E, Milton S C F, et al. Improved purities for Fmoc-amino acids from Fmoc-ONSU[J]. International Journal of Peptide and Protein Research, 1987, 30(3):431-432.
  [5] XIE Ji-zhong (谢继忠). Synthesis of Fmoc-linker and study on the protection of amino acid (Fmoc-链接剂的合成与保护氨基酸的合成研究)[D]. Shanghai (上海):East China University of Science and Technology (华东理工大学), 2013.
  [6] BAI Jie (白洁), ZHU Jie (祝杰), YE Shi-chao (叶世超), et al. Research on micro-dispersion and mass transfer coeffient of phosphoric acid extraction with n-butanol (正丁醇萃取磷酸的微分散过程与传质系数研究)[J]. Journal of Chemical Engineering of Chinese Universities (高校化学工程学报), 2015, 29(2):292-297.
  [7] SHU Cheng-liang (舒成亮), CAI Jin (蔡谨), WANG Jin (王金), et al. Conditions of separation butyric acid from fermentation broth by complexation extraction (发酵液中丁酸络合萃取分离条件的研究)[J]. Chemical Engineering (China) (化学工程), 2011, 39(8):11-15.
  [8] DAI You-yuan (戴猷元), YANG Yi-yan (杨义燕), YANG Tian-xue (杨天雪). Treatment of phenolic wastewater by complexation extraction (络合萃取法处理含酚废水技术)[J]. Chemical Industry and Engineering Progress (化工进展), 1991, 10(6):40-46.
  [9] HUANG Ying-yi (黄颖怡), ZHANG Jin (张瑾), DAI You-yuan (戴猷元). Study on extraction of aromatic acid based on chemical complexation (芳香酸稀溶液的络合萃取研究)[J]. Environmental Chemistry (环境化学), 2000, 19(2):136-141.
  [10] SUN Hou-yong (孙后勇), SHI Yun-hai (施云海), CAO Hai-yong (曹海甬), et al. Reactive extraction of glycolic acid in high content solution with tri-n-octylamine (含高浓度羟基乙酸溶液的络合萃取分离)[J]. Journal of Chemical Engineering of Chinese Universities (高校化学工程学报), 2007, 21(1):26-30.
  [11] King C J. Separation process based upon reversible chemical complexation//rousseau R W. Handbook of separation process technology[M]. New York:John Wiley & Sons, 1987.
  [12] JIANG Yun-liang (江运良), CAI Xin-xing (蔡新兴), WU Hao (吴昊), et al. Determination of liquid-liquid phase equilibrium data in N-butanol and water system and research on salting-out effect (正丁醇-水体系液液相平衡数据测定及盐析效应研究)[J]. Chemical Production and Technology (化工生产与技术), 2015, 22(4):32-34.
  [13] WANG Kai-yi (王开毅), CHENG Ben-cheng (成本诚), SHU Wan-yin (舒万银). Solvent extraction chemistry (溶剂萃取化学)[M]. Changsha (长沙):Central South University of Technology Press (中南工业大学出版社), 1991.