荆淑莹,史策,姚善泾,林东强

• 1:浙江大学 生物质化工教育部重点实验室，浙江大学 化学工程与生物工程学院，浙江 杭州 310027

摘要(Abstract)：

连续生物制造是生物制药的发展趋势，其中连续流层析是关键环节。作者根据近年来国内外连续流层析的研究进展，着重介绍了产物捕获和精制阶段的连续流层析技术，分析了不同模式的技术差异、各自特点和应用现状。针对未来发展趋势，进一步介绍了整合连续流层析过程，以及用于抗体连续生产的难点和挑战。作为一项新兴技术，抗体连续生产具有提高过程产率和产品质量、促进设备小型化和流程自动化、拓展过程灵活性和可靠性、降低生产成本等显著优势，但尚有不少方面需要改进和深化，包括过程设计、过程分析技术和过程控制技术等，特别是基于模型的预测分析和控制方法。

关键词(KeyWords)： 连续流层析;抗体;捕获;精制;过程集成;过程分析技术

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金（21776243，22078286）；上海市产业转型升级发展专项资金（工业强基GYQJ-2018-02-01）；中央高校基本科研业务费专项资金。

作者(Author): 荆淑莹,史策,姚善泾,林东强

DOI: 10.3969/j.issn.1003-9015.2021.01.001

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