杜煌,薛腾,唐二军,袁淼,刘少杰,赵地顺

• 1:河北科技大学 化学与制药工程学院，河北省药物化工工程技术中心，河北 石家庄 050018

摘要(Abstract)：

在离子液体氯化-1-烯丙基-3-甲基咪唑中，利用原子转移自由基聚合（ATRP）法在微晶纤维素（MCC）上接枝了pH敏感性的聚4-乙烯基吡啶（P4VP），合成了具有pH敏感性的药物载体材料MCC-g-P4VP。通过对亲水性模型药物罗丹明B和疏水性模型药物阿司匹林的包载及体外释放，研究了胶束对亲水性药物和疏水性药物的释放机制。利用FT-IR、NMR、GPC、TEM、XRD和UV-Vis等分析手段对聚合物的结构、胶束形貌、胶束对药物的载药性能及释药性能进行了表征分析。结果表明：MCC-g-P4VP聚合物胶束对两种药物的包载效果较好，载药胶束具有球状的核壳结构，载药胶束在药物释放过程中表现出了良好的pH敏感性且在酸性条件下的药物释放符合一级动力学模型，疏水性药物从胶束中释放的过程具有更加明显的pH敏感性。

关键词(KeyWords)： 原子转移自由基聚合;纤维素聚合物;载药胶束;pH敏感性;动力学模型

Abstract:

Keywords:

基金项目(Foundation): 河北省自然科学基金（B2013208183）。

作者(Author): 杜煌,薛腾,唐二军,袁淼,刘少杰,赵地顺

DOI: 10.3969/j.issn.1003-9015.2017.00.015

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