奥美拉唑对映体的模拟移动床色谱分离过程模拟Simulation of Omeprazole Resolution by Simulated Moving Bed Chromatography
危凤,沈波,陈明杰
摘要(Abstract)：
模拟移动床色谱已成为一种重要的手性药物制备技术,其技术关键在于最佳运行点的确定。由于其过程复杂,用数学模型来确定最佳运行点,求解难度大,计算时间长。今以考虑传质阻力与轴向弥散的模拟移动床模型为基础,采用线上求解法,将模型方程沿空间方向离散,得到一组常微分方程,然后运用MATLAB提供的常微分求解器求解这一偏微分方程组,模拟了奥美拉唑对映体的模拟移动床色谱分离过程。研究结果表明,线上求解法结合MATLAB常微分求解器可快速、准确地求解模拟移动床模型,用于模拟移动床色谱分离过程的实时控制与优化。
关键词(KeyWords)： 模拟;模拟移动床;线上求解法;MATLAB;奥美拉唑
基金项目(Foundation): 浙江省自然基金(203158);; 宁波市博士基金(2004A610008)。
作者(Author): 危凤,沈波,陈明杰
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