气相催化氧化法烟酸的绿色合成研究Study on Green Synthesis of Nicotinic Acid by Gas-phase Catalytic Oxidation
黄海凤,朱冰春,卢晗锋,刘华彦,陈银飞
摘要(Abstract)：
以3-甲基吡啶为原料,用V2O5/TiO2系催化剂,采用气相氧化法一步合成烟酸。水与3-甲基吡啶分开进料,通入催化剂床层后混合进行反应。实验考察了V2O5用量、助剂、反应温度、进水量及空速等因素对催化剂活性的影响。当V2O5负载量为25%,反应温度320~340℃,3-甲基吡啶空速0.15~0.8h-1,空气、水、3-甲基吡啶的进料摩尔比为110∶100∶1时,烟酸的产率达到90%以上。
关键词(KeyWords)： 3-甲基吡啶;烟酸;气相氧化;V2O5/TiO2催化剂
基金项目(Foundation): 浙江省自然科学基金项目资助(202083)
作者(Author): 黄海凤,朱冰春,卢晗锋,刘华彦,陈银飞
参考文献(References)：
- [1]SUN Li-rong(孙丽荣),ZHANG Juan(张娟),GAO Pei-rong(高培荣).Synthesis and advance of nicotinic acid(烟酸的合成与进展)[J].Chemistry andAdhesion(化学与粘合),1996,2:107-109.
- [2]ZHU Bin-chun(朱冰春),WANG Yu-guang(王宇光),LU Han-feng(卢晗锋).Synthesis research advance of nicotinic acid(烟酸的合成方法进展)[J].ChemicalIndustryTimes(化工时刊),2004,18(2):1-4.
- [3]LU Min-zhu(吕民主),PAN Pu-dun(潘浦敦).Chemical synthesis of nicotinic acid(烟酸的化学合成)[J].FeedReserch(饲料研究),2001,(3):36-39.
- [4]WolfgangF H.揙ne-pot?reactions: a contribution to environmental protection[J].AppliedCatalysisA,2000(194-195):487-496.
- [5]Al択aevaE M,AndrushkevichT V,ZenkovetsG A, et al.Studies on the conditions of synthesis of picolinic acid by heterogeneous catalytic oxidation of2-picoline[J].CatalysisLetters,1998:54,149-152.
- [6]CHEN Ying-qi(陈英奇),DAI Li-yan(戴立言),YANG Neng-wei(杨能渭).Synthesis of2-pyridinealdehyde by catalyticoxidation of2-methylpyridine in gaseous phase(2-甲基吡啶气相催化氧化合成2-吡啶甲醛的研究)[J].J ChemEng ofChineseUniv(高校化学工程学报),2002,16(4):436-440.
- [7]HeinzD,HoelderichW F,KrillS, et al.V2O5/TiO2 catalysts for the vapor-phase oxidation of b-picoline:Influence of theTiO2-carrier[J].Journal ofCatalysis192:2000,1-10.
- [8]GoutamDeo,WachsI E.Effect of additives on the structure and reactivity of surface vanadium oxide phase inV2O5/TiO2 catalysts[J].Journal ofCatalysis,1994,146:335-345.
- [9]WachsI E,WeckhuysenB M.Structure and reactivity of surface vanadium oxide species on oxide supports[J].AppliedCatalysisA :General,1997,157:67-90.
- [10]YE Dai-qi(叶代启),LIANG Hong(梁红),HUANG Zhong-tao(黄仲涛).Study on interaction ofV2O5/TiO2 catalyst active constituent with the carrier(催化剂活性组分与载体相互作用研究)[J].ACTA Physico-ChimicalSinica(物理化学学报),1993,9(4):501-505.
- [11]XU Bo-lian(许波连),FAN Yi-ning(范以宁),LU Lu, el al(刘浏等).Dispersion state and catalytic property ofV-O species onV2O5/TiO2 catalyst surface(V2O5/TiO2催化剂表面钒氧化物种的分散状态和催化性能)[J].ScienceChina(SieresB)(中国科学B辑),2002,32(3):235-242.
- [12]SONG Zhao-xia,TetsuyaShishido,ErikoKadowakui, et al.CrystalineCrV1-xPxO4 catalysts for the vapor-phase oxidation of3-picoline[J].Journal ofCatalysis,2003,218:32-41.
- [13]ZanthoffH W,Sananes-SchultzM,BuchholzS A, et al.On the active role of water during partial oxidation of n-butane to maleic anhydride over(VO)2P2O7 catalysts[J].AppliedCatalysisA:General,1998,172:49-58.