β-蒿甲醚在五种有机溶剂中溶解度的测定与关联Measurement and Correlation of the Solubility for β-Artemether in Five Organic Solvents
江燕斌,李凯霞,张扬,邱学青
摘要(Abstract)：
采用重量法测量了288.35～322.75K温度范围内β-蒿甲醚在正丙醇、异丙醇、丙酮、乙酸乙酯及N,N-二甲基甲酰胺中的溶解度。结果表明β-蒿甲醚在五种有机溶剂中的溶解度均随温度的升高而增大,但在不同的溶剂中溶解度及其温度敏感性存在一定差异,在N,N-二甲基甲酰胺、乙酸乙酯和丙酮中的溶解度相对较大,而在正丙醇和异丙醇中的溶解度相对较小但对温度比较敏感。采用经验方程和理想溶液模型对实验数据进行了关联,计算值与实验值吻合良好。上述结果可为蒿甲醚结晶过程溶剂选择提供基础数据。
关键词(KeyWords)： β-蒿甲醚;溶解度;经验方程;理想溶液模型
基金项目(Foundation): 国家自然科学基金资助项目(20536020,20676046)
作者(Author): 江燕斌,李凯霞,张扬,邱学青
参考文献(References)：
- [1]WHO.WHO Monograph on GACP for Artemisia Annua L[M].Switzerland:WHO Press,2006.
- [2]Xiao Shuhua,Marcel Tanner,N’Goran E K et al.Recent investigations of artemether,a novel agent for the prevention of schistosomiasis japonica.mansoni and haematobia[J].Acta Tropica,2002,82(2):175-181.
- [3]Zhang Yang,Jiang Yan-bin,Li Kai-xia et al.Solubility ofβ-artemether in Methanol+Water and Ethanol+Water from288.85to331.95K[J].J Chem Eng Data,2009,54(4):1340-1342.
- [4]Wilhelm H L,Jacqueline Beaumatin.Gravimetric method for the determination of some cryptating agents[J].Analytical Chemistry,1974,46(14):2218-2219.
- [5]LUO Jian-mei(骆健美),JIN Zhi-hua(金志华),CEN Pei-lin(岑沛霖)et al.Measurement and correlation of the solubilities of natamycin in different solvents(纳他霉素在不同溶剂中溶解度的测定与关联)[J].J Chem Eng of Chinese Univ(高校化学工程学报),2008,22(5):733-738.
- [6]LI Dian-qing(李殿卿),LIU Da-zhuang(刘大壮),WANG Fu-an(王福安)et al.Solubilities of terephthalaldehydic,p-toluic,benzoic,terephthalic and isophthalic acids in N,N-dimethylformamide(对羧基苯甲醛、对甲基苯甲酸、苯甲酸、对苯二甲酸和间苯二甲酸在N,N-二甲基甲酰胺中的溶解度)[J].J Chem Eng of Chinese Univ(高校化学工程学报),2001,15(3):258-261.
- [7]Wang Lin-yan,Dai Li-yan,Lei Ming et al.Solubility of hexamethylenetetramine in a pure water,methanol,acetic acid,and ethanol+water mixture from(299.38to340.35K)[J].J Chem Eng Data,2008,53(12):2907-2909.
- [8]Stanley M W(斯坦利M.瓦拉斯).Phase Equilibria in Chemical Engineering(化工相平衡)[M].Beijing(北京):China Petroleum&Chemical Press(中国石化出版社),1991:444-446.
- [9]Prausnitz J M,Lichtenthaler R N,Azevedo E G et al.Molecular Thermodynamics of Fluid-Phase Equilibria[M].Englewood Cliffs:Prentice-Hall Inc,1984.