艾秀珍,沈波,危凤,任其龙

• 1:浙江大学宁波理工学院
• 2:浙江大学二次资源化工国家专业实验室

摘要(Abstract)：

用反相制备液相色谱法从辣椒碱类化合物中分离得到了高纯度辣椒碱单体。采用碳十八硅胶(ODS)柱(200mm×10.0mm),考察了流动相组成、进样浓度、进样体积和流动相流速等对分离的影响,确定了适宜的工艺操作条件:流动相为甲醇/水(75/25,v/v),进样浓度为180mg·mL-1,进样体积为2.08mL,流速为4.0mL·min-1。在该工艺条件下,得到的辣椒碱单体纯度为95.23%,回收率为93.27%,产率为4.38g·L-1·h-1,流动相消耗为0.087L·g-1。本工艺操作简便,分离效率高,产品质量好,为辣椒碱单体的制备研究提供了一种新的方法。

关键词(KeyWords)： 反相制备液相色谱;辣椒碱类化合物;辣椒碱单体;二甲基十八碳硅烷(ODS)

Abstract:

Keywords:

基金项目(Foundation): 宁波市工业攻关项目(2007B100012)

作者(Author): 艾秀珍,沈波,危凤,任其龙

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