葛根素大孔吸附树脂层析分离动力学Dynamics of Chromatographic Puerarin Separation Process in Macroporous Resin Column
许永兴,瞿海斌,陈赟,程翼宇
摘要(Abstract)：
大孔吸附树脂层析分离技术是中药分离纯化的一个重要手段。针对葛根提取液中的葛根素和大豆甙元的大孔吸附树脂柱层析分离过程,建立了普通速率动力学模型,模型考虑了层析过程中的轴向扩散、外扩散、内扩散和树脂内部的非线性吸附平衡,此动力学模型能准确模拟葛根素和大豆甙元的色谱行为。用该模型对葛根素和大豆甙元的层析分离进行了仿真研究,考察了流动相流速变化对葛根素和大豆甙元层析分离的影响,结果表明此动力学模型能用来指导葛根素和大豆甙元层析分离过程操作条件的优化。
关键词(KeyWords)： 大孔吸附树脂;层析动力学模型;葛根素;大豆甙元
基金项目(Foundation): 浙江省科技厅重大科技计划资助项目(021103549)。
作者(Author): 许永兴,瞿海斌,陈赟,程翼宇
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