环己酮二乙缩酮的合成工艺研究Studies on Synthesis of Cyclohexanone Diethyl Acetal
张世界,戴立言,王晓钟,陈英奇
摘要(Abstract)：
环己酮二乙缩酮广泛应用于医药中间体的合成,也可以用于合成1-乙氧基环己烯,继而用于合成高分子材料和医药中间体。其制备方法是以氯化铵为催化剂,原甲酸三乙酯为解水剂,由无水乙醇和环己酮缩合合成。此方法具有催化剂便宜易得,可回收,反应后处理方便,工业三废少,收率高等优点,是环境友好的清洁生产过程。今通过各种影响因素研究实验得出了合成的最佳工艺条件:环己酮用量为29.4g(0.3mol)时,环己酮与原甲酸三乙酯摩尔比1:1.2,环己酮与无水乙醇摩尔比1:3,催化剂0.006mol,回流下反应,反应时间90min,产品收率91.8%,产品纯度和结构由气相色谱、气质联用仪及核磁共振仪确定。
关键词(KeyWords)： 环己酮;原甲酸三乙酯;环己酮二乙缩酮;无水氯化铵;反应条件优化
基金项目(Foundation): 国家自然科学基金资助项目(20376072)。
作者(Author): 张世界,戴立言,王晓钟,陈英奇
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