李汝真,吴艳阳

• 1:华东理工大学 化工学院，上海 200237

摘要(Abstract)：

考察了利福霉素噁嗪与1-氨基-4-甲基哌嗪的摩尔比、浓度、时间和温度等对缩合反应的影响，探究了缩合反应的机理，并得到相关动力学数据，为利福平合成工艺的优化提供理论依据。结果表明，利福霉素噁嗪与1-氨基-4-甲基哌嗪适宜的摩尔比为1：2；浓度对反应影响较小；反应时间越长或温度越高，利福霉素噁嗪的转化率和利福平的收率增加。缩合反应分两步进行，首先噁嗪开环生成中间产物，而后由哌嗪取代中间产物上的侧链，生成利福平。采用二级串联反应动力学模型对实验数据进行拟合，得到噁嗪开环反应的活化能为45.10 kJ·mol^-1，侧链取代反应的活化能为75.67 kJ·mol^-1。

关键词(KeyWords)： 利福平;利福霉素噁嗪;1-氨基-4-甲基哌嗪;反应机理;反应动力学

Abstract:

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基金项目(Foundation):

作者(Author): 李汝真,吴艳阳

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