纳他霉素在不同溶剂中溶解度的测定与关联Measurement and Correlation of the Solubilities of Natamycin in Different Solvents
骆健美,金志华,岑沛霖,王敏
摘要(Abstract)：
采用平衡法测定了纳他霉素在纯水(278.15～341.15K)和异丙醇(278.15～318.15K)、甲醇(278.15～313.15K)溶液中的溶解度。在三种溶剂中的溶解度均随温度升高而增大,以在甲醇中溶解效果最好,异丙醇次之,纯水最差。分别用经验模型、理想溶解度方程和Apelblat方程对实验数据进行关联,关联效果令人满意,平均相对误差小于5%,获得了相关模型参数。相对而言,经验模型和Apelblat方程关联的效果较好。实验得到的溶解度数据和关联结果对纳他霉素结晶工艺的研究具有较大的指导意义。
关键词(KeyWords)： 纳他霉素;溶解度;模型关联;平衡法
基金项目(Foundation): 浙江省重大科技攻关项目(2004C13007);; 天津科技大学引进人才科研启动基金(20060426);; 天津市应用基础研究计划面上项目(07JCYBJC07800);; 国际科学基金(F/4239-1)
作者(Author): 骆健美,金志华,岑沛霖,王敏
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