SEDS技术制备水飞蓟素纳米颗粒Preparation of Silymain Nanoparticles by SEDS Technique
于文利,陈蓓怡,赵亚平,蒋思媛
摘要(Abstract)：
采用超临界流体增强溶液分散技术(SEDS)从丙酮溶液中沉淀制备水飞蓟素纳米颗粒,用扫描电镜考察了工艺参数温度(25℃,32℃,40℃,50℃)、压力(9.5MPa,12MPa,15MPa,20MPa)、溶液浓度(40mg.mL-1,60mg.mL-1,80mg.mL-1,100mg.mL-1,120mg.mL-1)对颗粒形貌、粒径尺寸及粒径尺寸分布的影响。结果表明,所得颗粒均为实心微球;温度和溶液浓度是影响粒径尺寸的主要因素,降低温度和浓度能够显著减小粒径尺寸;温度也对粒径尺寸分布影响显著,在40℃时,粒径尺寸分布较窄,当温度高于或低于40℃时,粒径尺寸分布明显变宽。通过优化工艺参数,在9.5MPa,40℃,60mg.mL-1的条件下,制备出粒径尺寸介于100~300nm的水飞蓟素纳米颗粒。
关键词(KeyWords)： 超临界流体;水飞蓟素;纳米颗粒;微细化;SEDS
基金项目(Foundation): 上海市科委纳米专项(0243nm097)。
作者(Author): 于文利,陈蓓怡,赵亚平,蒋思媛
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