朱宪,王振武,郭晓亚

• 1:上海大学环境与化学工程学院化工系
• 2:上海大学环境与化学工程学院化工系
• 3:上海大学环境与化学工程学院化工系 上海201800
• 4:上海201800

摘要(Abstract)：

薯蓣皂苷元是合成甾体激素类药物和甾体避孕药的重要中间体,传统工艺采用盐酸水解法将黄姜中的薯蓣皂苷水解生成薯蓣皂苷元,反应时间4h,最大收率为1.78%。该工艺反应时间长,耗水量大,对环境污染严重。今研究了无催化剂条件下,近临界水中薯蓣皂苷水解成薯蓣皂苷元的工艺,分别考察了反应温度、反应压力、反应时间等因素对薯蓣皂苷元收率的影响。研究结果表明,近临界水解法工艺简单,反应时间短,对环境友好,在较佳工艺条件下:P=25.0MPa,T=260℃,t=10min,薯蓣皂苷元收率为1.46%。

关键词(KeyWords)： 清洁生产;近临界水;水解反应;薯蓣皂苷;薯蓣皂苷元

Abstract:

Keywords:

基金项目(Foundation): 上海市第二期重点学科项目(T-105)

作者(Author): 朱宪,王振武,郭晓亚

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