朱智博,关水,王树萍,王先犇,刘天庆,马学虎

• 1:大连理工大学干细胞与组织工程实验室

摘要(Abstract)：

引入多壁碳纳米管(multi-walled carbon nanotubes,MWCNTs)对壳聚糖/明胶/透明质酸(chitosan/gelatin/hyaluronic acid,Cs/Gel/HA)复合支架性能进行优化。采用冷冻干燥法制备出MWCNTs含量为2%、6%以及10%的Cs/Gel/HA/MWCNTs导电支架,对支架的理化性能及生物相容性进行评价。导电支架孔径为90~130μm,孔隙率为83%~96%;扫描电镜(SEM)及接触角测量结果显示,MWCNTs增加了孔壁粗糙度,提高了支架疏水性;支架电导率随MWCNTs含量的增加而增大,最大可增加至对照组的133.82%;MWCNTs含量为6%的支架细胞活力可增加至对照组的111.07%,且具有更高的细胞粘附率。研究初步表明,制备的Cs/Gel/HA/MWCNTs导电支架具有更好的生物相容性,可进一步应用于神经组织工程研究。

关键词(KeyWords)： 多壁碳纳米管;PC12细胞;导电支架;生物相容性

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(31670767);; 中央高校基本科研业务费专项资金资助项目(DUT16QY08,DUT16RC(3)098,DUT16ZD227)

作者(Author): 朱智博,关水,王树萍,王先犇,刘天庆,马学虎

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