凌慧,郑成,毛桃嫣,钟景铭

• 1:广州大学化学化工学院
• 2:广州科技职业技术学院

摘要(Abstract)：

化妆品的功效不仅在于其活性成分,也取决于载体系统。研究采用高压均质法制备包覆二苯酮-3(BP-3)和对甲氧基肉桂酸辛酯(OMC)两种紫外线吸收剂的纳米结构脂质载体(NLC),并采用扫描电镜、红外光谱、X射线衍射、差示扫描量热法等手段对其结构进行了表征分析。通过正交实验确定了最优配方为:防晒剂(OMC:BP-3=4:1)占总油相10%,总油相占配方6%,液体脂质占总脂质25%,乳化剂(A165:泊洛沙姆188:大豆卵磷脂=3:3:1)占配方4%,得到的NLC中BP-3和OMC包封率的分别为93.2%、98.8%。对紫外吸收性能和光稳定性进行测试,结果显示:包覆防晒剂的NLC比普通乳液的紫外吸收能力好,而且被包覆的防晒剂光异构化程度降低。这项研究为紫外吸收剂提供了一个合适的胶体脂质载运系统,NLC成为一个成功的光保护纳米制剂。

关键词(KeyWords)： 纳米结构脂质载体;防晒剂;包封率;表征;性能

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(21676061);; 广州市科技计划项目(201607010080)

作者(Author): 凌慧,郑成,毛桃嫣,钟景铭

参考文献(References)：

• [1]Chen L,Hu J Y,Wang S Q.The role of antioxidants in photoprotection:a critical review[J].Journal of the American Academy of Dermatology,2012,67(5):1013-1024.
• [2]González S,Fernández-Lorente M,Gilaberte-Calzada Y.The latest on skin photoprotection[J].Clinics in Dermatology,2008,26(6):614-626.
• [3]Teeranachaideekul V,Müller R H,Junyaprasert V B.Encapsulation of ascorbyl palmitate in nanostructured lipid carriers(NLC)—effects of formulation parameters on physicochemical stability[J].International Journal of Pharmaceutics,2007,340(1):198-206.
• [4]Ou-Yang H,Stanfield J,Cole C,et al.High-SPF sunscreens(SPF≥70)may provide ultraviolet protection above minimal recommended levels by adequately compensating for lower sunscreen user application amounts[J].Journal of the American Academy of Dermatology,2012,67(6):1220-1227.
• [5]Vilela F M P,Fonseca Y M,Jabor J R,et al.Effect of ultraviolet filters on skin superoxide dismutase activity in hairless mice after a single dose of ultraviolet radiation[J].European Journal of Pharmaceutics and Biopharmaceutics,2012,80(2):387-392.
• [6]Díaz-Cruz M S,Llorca M,BarcelóD.Organic UV filters and their photodegradates,metabolites and disinfection by-products in the aquatic environment[J].Trends in Analytical Chemistry,2008,27(10):873-887.
• [7]Giokas D L,Salvador A,Chisvert A.UV filters:from sunscreens to human body and the environment[J].Trends in Analytical Chemistry,2007,26(5):360-374.
• [8]TIAN Yong-hong(田永红),ZHANG Wan-ping(张婉萍).Preparation and properties of sunscreening agent made of solid lipid nanoparticles loaded with butyl methoxybenzophenone(包覆丁基甲氧基二苯甲酮固体脂质防晒粒的制备及性能研究)[J].China Surfactant Detergent&Cosmetics(日用化学工业),2013,43(1):55-58.
• [9]Kova?evi?A B,Müller R H,Savi?S D,et al.Solid lipid nanoparticles(SLN)stabilized with polyhydroxy surfactants:preparation,characterization and physical stability investigation[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2014,444:15-25.
• [10]Das S,Ng W K,Tan R B H.Are nanostructured lipid carriers(NLCs)better than solid lipid nanoparticles(SLNs):development,characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs?[J].European Journal of Pharmaceutical Sciences,2012,47(1):139-151.
• [11]Chen C C,Tsai T H,Huang Z R,et al.Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers:physicochemical characterization and pharmacokinetics[J].European Journal of Pharmaceutics and Biopharmaceutics,2010,74(3):474-482.
• [12]Süt?B,Weber S,Zimmer A,et al.Optimization and design of an ibuprofen-loaded nanostructured lipid carrier with a 23 full factorial design[J].Chemical Engineering Research and Design,2015,104:488-496.
• [13]LIANG Rong(梁蓉),WU Li-na(吴丽娜),YANG Cheng(杨成),et al.Application of co-enzyme Q10-loaded nanostructured lipid carriers in cosmetics(运载辅酶Q10的纳米结构脂质载体在化妆品中的应用)[J].China Surfactant Detergent&Cosmetics(日用化学工业),2016,46(9):524-529.
• [14]LI Xin-wei(李欣玮),SUN Li-xin(孙立新),LIN Xiao-hong(林晓宏),et al.Solid lipid nanoparticles as drug delivery system(固体脂质纳米粒作为药物载体)[J].Progress in Chemistry(化学进展),2007,19(1):87-92.
• [15]Puglia C,Bonina F.Lipid nanoparticles as novel delivery systems for cosmetics and dermal pharmaceuticals[J].Expert Opinion on Drug Delivery,2012,9(4):429-441.
• [16]LIU Xiao-hui(刘晓慧).Preparation and characterization of the nano solid lipid particles loaded UVA/UVB sunscreen(包覆UVA/UAB防晒剂的纳米固体脂质载体的制备和性能表征)[D].Shanghai(上海):Shanghai Institute of Technology(上海应用技术学院),2015.
• [17]Nikoli?S,Keck C M,Anselmi C,et al.Skin photoprotection improvement:synergistic interaction between lipid nanoparticles and organic UV filters[J].International Journal of Pharmaceutics,2011,414(1):276-284.
• [18]Mestres J P,Duracher L,Baux C,et al.Benzophenone-3 entrapped in solid lipid microspheres:formulation and in vitro skin evaluation[J].International Journal of Pharmaceutics,2010,400(1):1-7.
• [19]Niculae G,Badea N,Meghea A,et al.Coencapsulation of butyl-methoxydibenzoylmethane and octocrylene into lipid nanocarriers:UV performance,photostability and in vitro release[J].Photochemistry and Photobiology,2013,89(5):1085-1094.
• [20]Montenegro L,Sarpietro M G,Ottimo S,et al.Differential scanning calorimetry studies on sunscreen loaded solid lipid nanoparticles prepared by the phase inversion temperature method[J].International Journal of Pharmaceutics,2011,415(1):301-306.
• [21]Chen Y,Yang X,Zhao L,et al.Preparation and characterization of a nanostructured lipid carrier for a poorly soluble drug[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2014,455:36-43.
• [22]Soheyla H,Foruhe Z.Effect of zeta potential on the properties of nano-drug delivery systems-a review(Part 2)[J].Tropical Journal of Pharmaceutical Research,2013,12(2):265-273.
• [23]Li H L,Zhao X B,Ma Y K,et al.Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles[J].Journal of Controlled Release,2009,133(3):238-244.
• [24]Weiss J,Decker E A,Mc Clements D J,et al.Solid lipid nanoparticles as delivery systems for bioactive food components[J].Food Biophysics,2008,3(2):146-154.
• [25]Islan G A,Tornello P C,Abraham G A,et al.Smart lipid nanoparticles containing levofloxacin and DNase for lung delivery.Design and characterization[J].Colloids and Surfaces B:Biointerfaces,2016,143:168-176.
• [26]Kumar S,Randhawa J K.Solid lipid nanoparticles of stearic acid for the drug delivery of paliperidone[J].RSC Advances,2015,5(84):68743-68750.
• [27]Ali H,El-Sayed K,Sylvester P W,et al.Molecular interaction and localization of tocotrienol-rich fraction(TRF)within the matrices of lipid nanoparticles:evidence studies by Differential Scanning Calorimetry(DSC)and proton nuclear magnetic resonance spectroscopy(1H NMR)[J].Colloids and Surfaces B:Biointerfaces,2010,77(2):286-297.
• [28]Lacatusu I,Badea N,Murariu A,et al.The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles[J].Nanoscale Research Letters,2011,6(1):73.