郭海昌,郑人华,蒋华江,赵丹味,徐振元,夏爱宝

• 1:浙江工业大学浙江省绿色农药清洁生产技术研究重点实验室
• 2:台州学院医药化工与材料工程学院

摘要(Abstract)：

为研究在空气环境下经Heck反应制备3-苯基丙烯酸酯的合成方法,先在Fe_3O_4表面包裹聚多巴胺(PDA)形成Fe_3O_4@PDA亚微球,然后负载上纳米钯粒子(PdNPs)制备出Fe_3O_4@PDA-Pd NPs磁性复合物,再将该复合物用于催化卤代芳烃和丙烯酸酯的Heck反应,并对反应中的碱、溶剂、温度和催化剂用量等条件进行了优化。结果表明:催化剂用量为0.2%mol钯当量时,以三乙胺为碱,以N,N-二甲基甲酰胺为溶剂,80℃下反应3 h,碘代芳烃和丙烯酸酯经Heck反应制备3-苯基丙烯酸酯的收率大多在80%～90%;Fe_3O_4@PDA-PdNPs催化的Heck反应能在空气环境下进行,反应条件温和,对反应物取代基的耐受性好,催化剂分离简便。

关键词(KeyWords)： 四氧化三铁;Heck反应;纳米钯;3-苯基丙烯酸酯

Abstract:

Keywords:

基金项目(Foundation): 浙江省自然科学基金(LY18B020017);; 浙江省公益技术研究计划(LGG19B040001);; 台州市科技计划项目(1801gy21)

作者(Author): 郭海昌,郑人华,蒋华江,赵丹味,徐振元,夏爱宝

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