吴洁,丁师杰,陈静,刘超,黄娟娟

• 1:淮阴工学院生命科学与化学工程学院江苏省凹土资源利用重点实验室江苏省介入医疗重点实验室

摘要(Abstract)：

将凹凸棒黏土(ATP)与海藻酸钠(SA)进行复合以改善SA的缓释性能。以ATP/SA复合物为球芯材料,壳聚糖(CS)为包覆材料,采用复凝聚法制备凹土/海藻酸钠/壳聚糖复合微球(ASCM),并以双氯芬酸钠(DS)为模型药物,考察了凹土添加量对复合微球溶胀性能、载药性能和缓释性能的影响。结果表明,凹土的加入改善了微球的溶胀性能和缓释性能,而对微球载药性能影响不大。与海藻酸钠/壳聚糖微球(SCM)相比,当复合微球中ATP/SA(w/w)为20%时,其在pH6.8的磷酸缓冲溶液中2 h的累积释放率由58.8%减小到38.7%。复合微球体外释放动力学数据表明,其释药行为可以很好地用一级动力学方程拟合。凹土的加入有效改善了SA的缓释性能,ASCM可作为缓释药物的载体材料。

关键词(KeyWords)： 凹凸棒粘土;海藻酸钠;复合微球;缓释

Abstract:

Keywords:

基金项目(Foundation): 江苏省教育厅高校科研成果产业化推进项目(JHB2012-57);; 国家自然科学基金(21174046,51174096);; 淮安市“533”英才工程项目

作者(Author): 吴洁,丁师杰,陈静,刘超,黄娟娟

参考文献(References)：

• [1]Li Zhu-lai,Chen Peng.Preparation of chitosan-sodium alginate microcapusules containing ZnS nanoparticles and its effect on the drug release[J].Mater Sci Eng C,2009,29(7):2250-2253.
• [2]GONG Wei(龚伟),YANG Yang(杨阳),JIN Yi-guang(金义光),et al.The research progress of drug delivery system(新型药物递送系统研究进展)[J].Scientia Sinica Vitae(中国科学:生命科学),2011,41(10):894-903.
• [3]QI Liang-liang(漆亮亮),YING Xiao-guang(英晓光),LI Xiao(李晓),et al.Preparation of polyvinyl acetate-grafted-calcium alginate beads(乙酸乙烯酯接枝改性海藻酸钙凝胶微球)[J].Chemical industry and engineering progress(化工进展),2012,31(7):1555-1561.
• [4]WU Min(吴敏),NI Cai-hua(倪才华).Preparation of alginate gel modified by anise aldehyde and controlled release(大茴香醛改性海藻酸钠凝胶的制备及释药性能)[J].Chemical Research and Application(化学研究与应用),2012,24(3):400-403.
• [5]Pongjanyakul T,Rongthong T.Enhanced entrapment efficiency and modulated drug release of alginate beads loaded with drug-clay intercalated complexes as microreservoirs[J].Carbohyd Polym,2010,81(2):409-419.
• [6]HUANG Hai-tao(黄海涛),ZHAI Zhi(翟智),HUI Zhong-ying(惠忠英),et al.Drug-release property of carbon nanotube-loaded alginate microspheres as drug carrier(碳纳米管复合海藻酸微球药物载体的释药性能)[J].J Wuhan Univ(Nat.Sci.Ed.)(武汉大学学报(理学版)),2010,56(3):263-267.
• [7]Chen J,Jin Y L,Qian Y H,et al.A new approach to efficiently disperse aggregated palygorskite into single crystals via adding freeze process into traditional extrusion treatment[J].Ieee T nanotechnol,2010,9(1):6-10.
• [8]Singh B,Sharma D K,Kumar R,et al.Controlled release of the fungicide thiram from starch-alginate-clay based formulation[J].Appl Clay Sci,2009,45(1-2):76-82.
• [9]WU Jie(吴洁),CHEN Jin(陈静),SHU Chang(舒畅),et al.Preparation and characterization of attapulgite/chitosan resin microspheres(凹凸棒石粘土/壳聚糖复合树脂微球的制备与表征)[J].Journal of the Chinese ceramic society(硅酸盐学报),2011,39(7):1201-1205.
• [10]Aguzzi C,Cerezo P,Viseras C,et al.Use of clays as drug delivery systems:Possibilities and limitations[J].Appl Clay Sci,2007,36(1-3):22-36.
• [11]CHEN Yan(陈岩),ZHAO Yi-jiang(赵宜江),ZHOU Shou-yong(周守勇),et al.Study on polyacrylamide/attapulgite Adsorbent Composite(聚丙烯酰胺/凹凸棒粘土复合吸附材料的研究)[J].J Chem Eng of Chinese Univ(高校化学工程学报),2010,24(2):274-279.
• [12]Wang Q,Zhang J P,Wang A Q.Preparation and characterization of a novel pH-sensitive chitosan-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium[J].Carbohyd Polym,2009,78(4):731-737.
• [13]Chinese Pharmacopoeia Commission(中国药典委员会).Chinese pharmacopoeia(中国药典,二部)[M].Beijing(北京):Chinese Medicine Science and Technology Press(中国医药科技出版社),2010.
• [14]XI Guo-xi(席国喜),TIAN Sheng-jun(田圣军),CHENG Qing-tan(成庆堂),et al.Studies on thermal dissociation of sodium alginate(海藻酸钠的热分解研究)[J].Chemical world(化学世界),2000,41(5):254-258.
• [15]WANG Qin(汪琴),ZHANG Jun-ping(张俊平),WANG Ai-qin(王爱勤).Preparation and properties of drug loaded hydrogel beads based on halloysite(基于埃洛石的载药凝胶小球的制备及性能研究)[J].Chemical Research and Application(化学研究与应用),2010,22(7):858-863.
• [16]SHANG Dan(商丹),ZHANG Chao-ping(张朝平),SHEN De-jun(申德君).The preparation and controlled release of magnetic gelatin drug microsphere of ampicillin(氨苄西林磁性明胶药物微球的制备及控制释放)[J].J Chem Eng of Chinese Univ(高校化学工程学报),2009,23(3):537-542.
• [17]DING Yun-sheng(丁运生),ZHANG Zhi-cheng(张志成),SHI Tie-jun(史铁均).Progress and research of impermeable polymer materials(阻隔性高分子材料研究进展)[J].Journal of functional polymer(功能高分子学报),2001,14(3):360-364.
• [18]CUI Fu-de(崔福德).Pharmaceutics(药剂学)[M].Beijing(北京):People Hygiene Press(人民卫生出版社),2003.