肾脏组织冷灌注过程的物性参数研究Analysis of Physical Parameters of Kidney Tissues during Cold Perfusion Processes
张密,诸凯,梁飞,王雅博,安娜
摘要(Abstract):
目前许多学者致力于研究低温保存过程中生物组织材料的力学性能。在冷灌注过程中,内部温度的不均匀导致组织产生热应力,对生物组织造成损伤。为了更好地了解这一现象,研究重点定量考察温度与线性热膨胀系数和杨氏模量的关系,并应用一种新的方法测量肾脏组织在降温过程中产生的热应变。这种方法是利用低温显微系统获取不同降温速率下的肾脏组织图像,然后应用Vic-2D软件分析肾脏组织在特定温度和参照温度下所拍图像之间的微小形变,从而获得热应变数值。而杨氏模量是利用静态拉伸法测定不同温度下组织应力及应变,拟合出其杨氏模量数值。实验结果显示在0~20℃内,线性热膨胀系数是随着温度的降低而升高的;而杨氏模量在这个温度范围内保持恒定。
关键词(KeyWords): 生物组织;热应力;线性热膨胀系数;杨氏模量
基金项目(Foundation): 国家自然科学基金(51076117)
作者(Author): 张密,诸凯,梁飞,王雅博,安娜
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