曾与萱,程丽萍,赵珺,陈国

• 1:华侨大学 化工学院，福建 厦门 361021

摘要(Abstract)：

DNA水凝胶是DNA分子链在水溶液中交联形成的三维网状结构，是生物技术及新材料领域的研究新热点。由于DNA分子卓越的特异性与可设计性，利用DNA分子形成具有拓扑结构的DNA水凝胶在实现水凝胶可设计性的同时也能具有智能响应性，在药物运输、生物传感等领域展现出广泛的用途，但该凝胶的制备仍然面临成本高昂及成胶效率低下等问题。滚环扩增技术作为一种新型的酶介导等温扩增方式，极大地节省了合成成本，同时也为单链DNA的有效扩增提供了新的方法，将凝胶的制备变得方便快捷，并且在此基础上赋予其独特的性质。本综述主要介绍了近年来基于滚环扩增制备的新型DNA水凝胶，并对其设计理念、形成机理、优势与难点进行讨论。

关键词(KeyWords)： DNA水凝胶;滚环扩增;智能响应;序列设计

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金（21606094，21576108）；福建省自然科学基金（2018J01009）；华侨大学研究生科研创新能力培育计划。

作者(Author): 曾与萱,程丽萍,赵珺,陈国

DOI: 10.3969/j.issn.1003-9015.2021.05.004

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