孙坚,卢凌美,蒋珺,李坚军

• 1:浙江工业大学药学院国家化学原料药合成工程技术研究中心

摘要(Abstract)：

为了高效简便合成1-氨甲基-2-萘酚类化合物,选择以β-萘酚、醛和胺为起始原料,在有机小分子三氟甲磺酸脯氨酸盐的催化下,一锅法合成了该类化合物。重点考察了不同有机小分子催化剂以及不同溶剂对该反应的影响,确定了适宜的反应条件为:n(β-萘酚):n(醛):n(胺):n(三氟甲磺酸脯氨酸盐)=1:1:1.1:0.1,于二氯甲烷溶剂中回流反应。同时,合成的系列目标化合物,结构经过熔点、IR、~1H-NMR、~(13)C-NMR和MS确认。此外,还将该方法应用于α-萘酚及芳胺中,合成了相应的产物,并探讨了可能的反应机理。

关键词(KeyWords)： 1-氨甲基-2-萘酚类化合物;三氟甲磺酸脯氨酸盐;多组分反应;反应机理

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(21776254)

作者(Author): 孙坚,卢凌美,蒋珺,李坚军

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