关今韬¹,贠军贤²,关怡新¹,姚善泾¹

• 1:浙江大学 化学工程与生物工程学院，浙江 杭州 310027
• 2:浙江工业大学 化学工程学院 绿色化学合成技术国家重点实验室培育基地，浙江 杭州 310032

摘要(Abstract)：

以可再生资源发酵制备的光学纯苯乳酸为单体合成的聚苯乳酸，是最新研究的一种芳香族生物基聚合物新材料，具有优异的热稳定性、机械强度和紫外吸收性能，成为继聚乳酸材料之后的重要聚合物材料，在工业领域具有潜在的广阔应用前景。高纯度苯乳酸单体的制备是聚苯乳酸工业化的关键。本文从聚苯乳酸的合成、苯乳酸单体的化学与生物合成方法及下游分离纯化等方面，对其研究现状进行了综述。苯乳酸的化学合成法有多条明确的路线，但步骤繁琐，反应条件苛刻，副产物多，尚不能工业化应用；生物合成法制备苯乳酸的反应条件温和，具有很好的可持续性；用生物安全性优良的高产菌株进行生物转化及酶法合成，成为苯乳酸工业化发展的重要方向。但是，采用常规纯化方法从生物发酵液或转化液中分离纯化得到苯乳酸时，尚存在处理量较小、工艺繁琐、反应条件苛刻等局限性；近几年兴起的晶胶介质层析分离技术，可简化分离纯化步骤，其产物纯度高，过程简便，有望成为苯乳酸分离的新方法。

关键词(KeyWords)： 聚苯乳酸;苯乳酸;化学合成;生物合成;晶胶介质

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金（21576240）；浙江省自然科学基金（LZ14B060001，LY16B060011）

作者(Author): 关今韬¹,贠军贤²,关怡新¹,姚善泾¹

DOI: 10.3969/j.issn.1003-9015.2018.04.001

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