阿维菌素在不同醇-水溶剂体系中溶解度的测定与关联Determination and Correlation of Solubilities of Avermectins in Different Systems of Alcohol-Water
孙鹏,刘俊果,杨玉淮,刘琳
摘要(Abstract)：
工业生产中阿维菌素在不同比例的有机溶剂-水体系中的溶解度是重要的基础数据,本实验采用平衡法测定了阿维菌素在甲醇含量100%～70%、乙醇含量100%～60%的水溶剂中,温度范围为30～70℃的溶解度,并采用多项式经验方程、半经验关联模型对实验测定溶解度数据进行关联,相关系数都在98%以上,结果较为满意。结果表明在甲醇-水溶剂体系中随水的比例增加,溶解度减少较为明显,以32℃时为例,90%甲醇-水溶剂比纯甲醇做溶剂的溶解度下降了67%,而乙醇-水体系随水的比例增加,溶解度减小较缓和,同样条件下,在95%乙醇-水溶剂中溶解度只下降了28%。
关键词(KeyWords)： 阿维菌素;溶解度;关联;平衡法
基金项目(Foundation): 河北科技大学科研基金资助课题
作者(Author): 孙鹏,刘俊果,杨玉淮,刘琳
参考文献(References)：
- [1]QIU Si-xin(邱思鑫),HUANG Tian-pei(黄天培),GUAN Xiong(关雄).Advances and prospect of avermectin application(阿维菌素的应用现状与展望)[J].Fujian Agricrltural Science and Technology(福建农业科技),2000,46(s1):96-97.
- [2]HE Huan-jun(何焕君),Qiu Li-na(邱丽娜),YAO Wei-fang(姚伟芳)et al.Study on the development of avermectins(阿维菌素的研究进展)[J].Biotechnology(生物技术),2006,16(6):84-85.
- [3]TIAN Yi-min(田益民),YANG Hong(杨红),LI Yan-fang(李艳芳).Improvement of avermectin crystallization technology(阿维菌素结晶工艺的改进)[J].Chinese Journal of Pharmaceuticals(中国医药工业杂志),2002,33(9):432-433.
- [4]SONG Yuan(宋渊).Studies on commercialization of avermectins(阿维菌素的工业化生产研究)[J].Fine and Specialty Chemicals(精细与专用化学品),2002,21(1):57-60.
- [5]XIE Zhi(谢智),JI Qing-rong(季清荣),CHANG Zhi-dong(常志东).Determination and correlation of solubilities of avermectins in different solvents.(Avermectin在不同溶剂中溶解度的测定与关联)[J].Chinese Journal of Antibiotics(中国抗生素杂志),2006,31(1):42-44.
- [6]YE Chang-shen(叶长燊),LIN Cheng(林诚),QIU Ting(邱挺).Determination and correlation of liquid-liquid equilibrium data for the ternary system of DMF-CHCl3-H2O(N,N-二甲基甲酰胺-三氯甲烷-水体系液液相平衡数据的测定与关联)[J].J Chem Eng of Chinese Univ(高校化学工程学报),2009,32(2):183-186.
- [7]ZHANG Cong-liang(张从良),WANG Yan(王岩).Determination and correlation of aqueous solubilities for quinolones(喹诺酮类药物水溶解度的测定与关联)[J].J Chem Eng of Chinese Univ(高校化学工程学报),2009,23(1):175-177.
- [8]HAN Jin-yu(韩金玉),XIAO Jian(肖剑),WANG Hua(王华)et al.Measurement and correlation of taxol solubility in methanol,ethanol and methanol-water systems(紫杉醇溶解度的测定与关联)[J].J Chem Ind and Eng(China)(化工学报),2001,52(1):64-67.
- [9]LUO Jian-mei(骆健美),JIN Zhi-hua(金志华),CEN Pei-lin(岑沛霖)et al.Measurement and correlation of the solubilities of natamycin in different solvents(纳他霉素在水和甲醇中溶解度的测定与关联)[J].J Chem Ind and Eng(China)(化工学报),2008,59(2):281-268.
- [10]Dongwei Wei,Limei Chen.Solubility of 2-aminopyridine in acetone,chloroform,and ethyl acetate[J].Chem Eng Data 2009,54(3),1098-109.