2-甲基吡啶气相催化氧化合成2-吡啶甲醛的研究Synthesis of 2-Pyridinealdehyde by Catalytic Oxidation of 2-Methylpyridine in Gaseous Phase
陈英奇,戴立言,杨能渭
摘要(Abstract):
以碱性皂土为载体,钒、钼为活性组份的催化剂气相选择性催化氧化2-甲基吡啶制备2-吡啶甲醛; 考察了反应温度、氧气用量及液体进料速度等因素对催化剂活性的影响。结果表明:在反应温度为290~300℃,空气流速为220mL h-1,钒钼活性组份以氧化物计的摩尔比为1:1.26,液体进料速度为25mL h-1时,原料的转化率为50%~58%,反应的选择性为80%~90%,收率为43%~50%。
关键词(KeyWords): 2-吡啶甲醛;催化氧化;钒钼催化剂
基金项目(Foundation):
作者(Author): 陈英奇,戴立言,杨能渭
参考文献(References):
- [1]LI Jin-yu(李锦玉),YU You-ping(俞有平),DAI Rong, et al.(戴荣等),Synthesis ofBisacodyl(比沙可啶的合成)[J].ChineseJournal ofPharmaceuticals(中国医药工业杂志),1993,24(2):53-54.
- [2]JadonS C S,FahmiM N,SinyhR V.Synthetic and biological aspects of some hetero chelates of dioxomolybdenum(Ⅵ) with nitrogen-sulfur donor ligands[J].SynthReactInorgMet-OrgChem,1995,25(8):1345-63.
- [3]BroomN J P,EdwardsP D,OsborneN P.6-Alkylidenepenems their preparation and their use as antibiotics[P].WO8700525,1987.
- [4]CushmanM S,HamelE.Stilbene derivatives as anticancer agents[P].US5430062,1995.
- [5]LiuL,QueenerS F,AbrahanA et al.Nonclassical analogs of10-deazaaminopterin: synthesis and inhibition of rat liver[J].MedChemRes,1994,4(3):211-21.
- [6]TsudaY,MishinaT,ObataM, et al.Preparation of dihydroazolopyridines as calcium antagonists or agonists[P].US4918074,1990.
- [7]BernareggiV,BonifacioF,FanoM, et al.Preparation of tetrazolyamide derivatives of hetrocyclylalkenyl acids and their use as allergy inhibitors[P].EP384450,1990.
- [8]BroorsC D W,StewartA O,CraigR A.Preparation of anti-inflammatory substituted aryl and heteroarylalkenyl-N-hydroxyurea inhibitors of leurotriene biosynthesis[P].WO9530671,1995.
- [9]FujiphotoFilmCoLtd.Method of processing of color photographic materials[P].JP59214855,1984.
- [10]MinamidaI,IwangaK,OkauchiT.Alpha-unaturated amines particularly1,1-diamino-2-nitroethylene derivatives their insecticidal/miticidal compositions[P].EP302389,1989.
- [11]BoldG,LangM,FaesslerA.Preparation of dipeptide derivatives of5-amino-4-hydroxyhexanoic acid asHIV protease inhibitors[P].EP618222,1994.
- [12]SHAN Shi-ming(单世明),YU Shu-qin(余书勤),LIAO Hong, et al.(廖红等),Synthesis of2-pyridinealdehyde(2-吡啶甲醛的合成)[J].ChineseJournal ofPharmaceuticals(中国医药工业杂志),1997,28(8):377-378.
- [13]LeiticsL,ShimanskayaM V.Vapor-phase oxidation of methylpyridines to pyridinecarboxaldehyde[J].KhimGeteroSoedim,1967,3:507-511.
- [14]SinghB C,NayakP L,PoutM K.Kinetics of oxidation of a-picoline by cerium(Ⅵ) in acetic acid[J].IndianJ Chem,1974,12(4):421-2.
- [15]GlubokovskikhL K,KanI I,SuvorovB V.Oxidative reactions of2,6-lutidine od fused vanadium pentoxide[J].SerKhim,1980,(5):51-54.
- [16]YUAN Zhi-qing(袁志庆),CAI Ye(蔡晔),SHEN Lian, et al.(慎栋等),Synthesis, characterization and reactivity of vanadium-containing mesoporous molecular sieves(钒硅中孔分子筛合成,表征及其催化性能研究)[J].J ChemEng ofChineseUniv(高校化学工程学报),2002,16(2):145-148.