钱超¹,高武成¹,付水香¹,陶明²,廖祖态²,陈新志¹

• 1:浙江省化工高效制造技术重点实验室，浙江大学 化学工程与生物工程学院，浙江 杭州 310027
• 2:江西仁明医药化工有限公司，江西 九江 332700

摘要(Abstract)：

以2-降莰烷酮为起始原料，通过Mannich反应、Baeyer-Villiger反应和缩合反应制得双环[3.2.1]辛烷-2，4-二酮。在Mannich反应中，采用水蒸汽蒸馏有利于产品的分离提纯、促进中间产物转化为最终产物，达到了反应分离的效果；在Baeyer-Villiger反应中，通过改变甲醇和双氧水的加料顺序可避免过度氧化，提高产品收率。优化条件下产品的总收率为61.5%。

关键词(KeyWords)： 2-降莰烷酮;反应分离;Mannich反应;Baeyer-Villiger反应;双环[3.2.1]辛烷-2,4-二酮

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金（21376213，21476194）；国家重点研发计划项目（2016YFB0301800）。

作者(Author): 钱超¹,高武成¹,付水香¹,陶明²,廖祖态²,陈新志¹

DOI: 10.3969/j.issn.1003-9015.2017.04.021

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