张维阳,崔兴,蒋淑娴,宋慧洁,周容帆,叶向群,何潮洪

• 1:浙江省化工高效制造技术重点实验室，浙江大学 化学工程与生物工程学院，浙江 杭州 310027

摘要(Abstract)：

左旋氧氟沙星是临床上常用的抗菌消炎药物，对于格兰阴性菌引起的各类炎症都有较好的治疗效果，其制备的一种方法是通过氧氟沙星消旋体进行手性拆分。手性拆分过程中氧氟沙星溶解度低、选择性系数小是目前急需解决的问题。研究使用乙酸增加了氧氟沙星在水相的溶解度，并利用L-酒石酸二乙酯对较高浓度的氧氟沙星进行了手性拆分。研究了萃取温度、L-酒石酸二乙酯浓度、氧氟沙星消旋体浓度以及乙酸浓度对于拆分过程的影响。结果表明，乙酸的加入能显著增大氧氟沙星在水相中的溶解度，在L-酒石酸二乙酯的浓度0.2 mol·L^-1，氧氟沙星浓度12000 ppm，萃取温度25℃，乙酸浓度0.1 mol·L^-1时，氧氟沙星对映体的手性拆分系数达到1.39。这对左旋氧氟沙星的制备有较重要的参考价值。

关键词(KeyWords)： 液液萃取;手性拆分;氧氟沙星;手性药物

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目（21576231）。

作者(Author): 张维阳,崔兴,蒋淑娴,宋慧洁,周容帆,叶向群,何潮洪

DOI: 10.3969/j.issn.1003-9015.2017.04.003

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