蒋姗姗,张其磊,关怡新,姚善泾

• 1:浙江大学化学工程与生物工程学院

摘要(Abstract)：

玉米醇溶蛋白是一种具有强疏水性的天然植物蛋白,在食品和医药等行业具有良好的应用潜力。本文采用强化混合超临界流体辅助雾化技术(SAA-HCM)制备玉米醇溶蛋白超细微粒,研究相关实验参数如混合气压力与温度、沉淀器温度、玉米醇溶蛋白浓度及乙醇浓度等对微粒形貌、粒径的影响。实验结果表明在9.0 MPa的混合器压力,混合器温度和沉淀器温度分别为50℃和60℃,玉米醇溶蛋白浓度为20 g?L-1,乙醇浓度为80%条件下,制得的微粒具有球形度高、分散性好、粒径可控制等优点,且平均粒径约为3μm。此外,本文以醇溶蛋白为载体、VD3为模拟活性药物制备载药微粒,并对其形貌、载药率和药物释放行为做初步探索,取得了合理的包埋缓释效果。

关键词(KeyWords)： 玉米醇溶蛋白;超临界流体辅助雾化;维生素D3;载药微粒

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年基金项目(21606194)

作者(Author): 蒋姗姗,张其磊,关怡新,姚善泾

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