非平衡双柱交替循环色谱分离过程模型Non-Equilibrium Model of Alternate Cycling Separation of Double-Column Chromatography
李忠,李湘,奚红霞,谢兰英
摘要(Abstract)：
循环色谱是一种新颖的分离技术，它以短柱多次循环分离模拟传统的长柱单循环色谱分离，并在分离的过程中不断把已被分离的组分切割抽出，缩短了操作周期时间，提高分离产率。本文建立了非平衡双柱交替循环色谱分离过程数学模型，并进行了双柱交替循环色谱分离蔗糖和还原糖实验和计算机模拟分析。研究结果表明，使用本文提出的非平衡双柱交替循环色谱模型计算得到的流出曲线与实验得到的流出曲线吻合很好。双柱循环色谱分离操作能比采用传统的色谱操作获得更高的分离产率，产率随着循环次数的增加而增大。当体系中轴向扩散较严重、液固两相间的传质阻力较大或表观选择性系数较小时，与采用传统的单长柱色谱操作方式比较，采用双柱交替循环色谱分离方式将能更明显地改善和提高分离产率。
关键词(KeyWords)： 双柱色谱;循环分离;模型;产率;蔗糖;还原糖
基金项目(Foundation): 国家自然科学基金资助项目!(No.29776022);; 广东省自然科学基金资助项目。
作者(Author): 李忠,李湘,奚红霞,谢兰英
参考文献(References)：
- [1] Seidel-Morgerstern A, Guiochon G. Theoretical study of recycling in preparative chromatography [J]. AIChE Journal, 1993, 39(5): 809-819.
- [2] LI Zhong (李忠), SHU Wen-li (舒文利), LI Xiang (李湘), ZHAO Yue-chun (赵月春). Non-linear and non-equilibrium cycling chromatography (非线性非平衡循环色谱研究)[J]. Journal of Chinese Chemical Engineering (化工学报), 1998(4) : 501-506.
- [3] Duvdevani I, Biesenberger J A, Tan M. Recycle gel permeation chromatography: III. Design modifications and some results with polycarbonate [J]. Polym Lett, 1971, (9): 429-438.
- [4] LING Bing-chang (林炳昌). Fundamental Theory of Nonlinear Chromatography Mathematical Model (非线性色谱数学模型理论基础) [M]. Beijing (北京):Science Publishing Company (科学出版社), 1994.
- [5] LI Zhong, ZHAO Yue-chun, SHU Wen-li, LIN Qing-sheng, YE Zhen-hua. A FAD-SMT model of large scale liquid adsorption chromatography [J]. Adsorption, 1999, 5(1): 73-79.
- [6] LI Xiang (李湘). Non-linear and Non-equilibrium Double-column and Double-valve Cycling Chromatography (非线形非平衡双柱双阀循环色谱研究)[D]. Guangzhou (广州):South China University of Technology (华南理工大学), 1999.
- [7] LI Zhong (李忠),YE Zheng-hua (叶振华). A new method of thermodynamic and dynamic parameter identification of large scale chromatography (大型液相色谱分离过程热力学动力学参数辨识新方法) [J]. Journal of Chinese Chemical Engineering (化工学报), 1994 (5): 601-610.
- [8] XU Qing-Cai (徐清才), HUANG Pei-quan (黄培泉), LI Zhong (李忠). Adsorption characteristics of sugar and reducing sugar on CR adsarbent (CR吸附剂对蔗糖还原糖的吸附特性) [J]. Journal of Chemical Engineering of Chinese Universities (高校化学工程学报), 1994 , 8 (1): 78 ~ 83.
- [9] SHU Wen-li (舒文利),LIU Tang-shu (刘唐书),LI Xiang (李湘),XU Qing-cai (徐清才),LI Zhong (李忠) The factors affecting the symmetry of chromatographic peak in liquid adsorptive chromatography (液相制备吸附色谱流出峰对称性的若干影响因素) [J]. Chromatography (色谱),1998, 16(5): 370-374 .