于玉振,张晓慧,李鹏坤,王荣荣,李战军,刘宇恒,李雯

• 1:药物关键制备技术教育部重点实验室
• 2:新药创制与药物安全性评价河南省协同创新中心
• 3:郑州大学化工与能源学院
• 4:郑州大学药学院

摘要(Abstract)：

通过平衡法测定了283.15~328.15 K温度下普瑞巴林晶型I在水、甲醇、乙醇、丙酮、四氢呋喃、N,N-二甲基甲酰胺、乙酸乙酯及丙酮-水混合溶剂中的溶解度,实验结果表明:普瑞巴林晶型I在所测定的所有纯溶剂及丙酮-水混合溶剂中的溶解度均随温度的升高而增大;在丙酮-水混合溶剂中,溶解度随着丙酮的摩尔分数的增加而降低,在丙酮的摩尔分数达到0.83附近时溶解度最小,接近0。采用修订的Apelblat经验方程和(CNIBS)/Redlich-Kister方程对溶解度数据进行关联,结果令人满意。所得实验数据和拟合模型为普瑞巴林在工业结晶及药物多晶型等方面的研究提供了重要的依据。

关键词(KeyWords)： 普瑞巴林;溶解度;测定;关联;模型

Abstract:

Keywords:

基金项目(Foundation): 河南省科技厅产学研合作项目(152107000043);; 河南省教育厅科学技术研究重点项目(914A5300007)

作者(Author): 于玉振,张晓慧,李鹏坤,王荣荣,李战军,刘宇恒,李雯

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