喹诺酮类药物水溶解度的测定与关联Determination and Correlation of Aqueous Solubilities for Quinolones
张从良,王岩
摘要(Abstract):
采用平衡法测定了293.15~323.15K温度范围内6种喹诺酮类药物的水溶解度数据,并运用λh方程进行了关联,确定了方程参数,6种药物的计算与实验值平均相对偏差最大为10.1%。结果表明,实验范围内6种喹诺酮类药物的水溶解度均较小,且分别随温度的升高而略有增加。
关键词(KeyWords): 喹诺酮类药物;水溶解度;平衡法;λh方程
基金项目(Foundation): 河南省自然科学基金项目(0611033400)
作者(Author): 张从良,王岩
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