多孔碳酸钙微粒的简易制备及其形貌控制Facile Synthesis and Morphology Control of Porous CaCO3 Microparticles
张腾龙,庞艺川,冯杰
摘要(Abstract):
以Na2CO3和Ca(NO3)2为反应物,聚苯乙烯磺酸钠(PSS)为表面活性剂,在室温水溶液中制备了多孔碳酸钙微粒。用FE-SEM对其微观形貌进行观察,发现通过改变PSS用量以及反应物浓度,可以控制微粒的粒径及形貌。在PSS用量为0.5 g?L?1、反应物浓度为0.025 mol?L?1时,合成的Ca CO3为多孔微球,且粒径均一,约为1.2μm。相应的XRD和BET测试显示,多孔Ca CO3微球为球霰石和方解石型的混合晶体。多孔Ca CO3微球表面的纳米孔孔径随反应物浓度增加而减小,比表面积则随之增大。
关键词(KeyWords): 多孔碳酸钙;制备;微球;形貌控制
基金项目(Foundation): 国家自然科学基金(51172206)
作者(Author): 张腾龙,庞艺川,冯杰
参考文献(References):
- [1]Yu S H,C?lfen H,Hartmann J,et al.Biomimetic crystallization of calcium carbonate spherules with controlled surface structure and size by double-hydrophilic block copolymers[J].Adv Funct Mater,2002,12(8):541-545.
- [2]Sukhorukov G B,Volodlkin D V,Günther A M,et al.Porous calcium carbonate microparticles as templates for encapsulation of bioactive compounds[J].J Mater Chem,2004,14(14):2073-2081.
- [3]Won Y H,Jang H S,Chung D W,et al.Multifunctional calcium carbonate microparticles:synthesis and biological applications[J].J Mater Chem,2010,20(36):7728-7733.
- [4]Volodkin D V,Klitzing R V,M?hwald H.Pure protein microspheres by calcium carbonate templating[J].Angew Chem Int Ed,2010,49(48):9258-9261.
- [5]Tong W J,Song X X,Gao C Y.Layer-by-layer assembly of microcapsules and their biomedical applications[J].Chem Soc Rev,2012,41(18):6103-6124.
- [6]Peng C Y,Zhao Q H,Gao C Y.Sustained delivery of doxorubicin by porous Ca CO3 and chitosan/alginate multilayers-coated Ca CO3microparticles[J].Colloids and Surface A:Physicochem Eng Aspects,2010,353(2-3):132-139.
- [7]LI Liang(李亮),ZHU Ying-jie(朱英杰),CAO Shao-wen(曹少文),et al.Preparation and drug release properties of nanostructured Ca CO3 porous hollow microspheres(碳酸钙纳米结构多孔空心微球的制备及其药物缓释性能研究)[J].J Inorganic Mater(无机材料学报),2009,24(1):166-170.
- [8]Kim S J,Park C B.Mussel-inspired transformation of Ca CO3 to be minerals[J].Biomaterials,2010,31(25):6628-6634.
- [9]Dey A,With G D,Sommerdijk N A.In situ techniques in biomimetic mineralization studies of calcium carbonate[J].Chem Soc Rev,2010,39(2):397-409.
- [10]Wei Q R,Lu J,Ai H,et al.Novel method for the fabrication of multiscale structure collagen/hydroxyapatite-microsphere composites based on Ca CO3 microparticle templates[J].Materials Letters,2012,80:91-94.
- [11]Zhong M Q,Zheng J Y,Feng J.Fabricating polymer superhydrophobic surface by porous spherical Ca CO3 particle layer as template[J].Chem J Chinese Universities,2010,31(12):2511-2517.
- [12]Tong H,Ma W T,Wang L L,et al.Control over the crystal phase,shape,size and aggregation of calcium carbonate via a L-aspartic acid inducing process[J].Biomaterials,2004,25(17):3923-3929.
- [13]Jada A,Pefferkom E.Smooth and rough spherical calcium carbonate particles[J].Journal of Materials Science Letter,2000,19(23):2077-2079.
- [14]Kim I W,Robertson R E,Zand R.Effects of some nonionic polymeric additives on the crystallization of calcium carbonate[J].Crystal Growth&Design,2005,5(2):513-522.
- [15]Yan G W,Huang J H,Zhang J F,et al.Aggregation of hollow Ca CO3 sphere by calcite nanoflakes[J].Materials Research Bulletin,2008,43(8-9):2069-2077.
- [16]Yan F W,Guo G Y,Zhang X H,et al.Synthesis and characterization of spherical porous calcium carbonate with ordered secondary structure in the presence of polymer with double hydrophilic ionic moieties[J].Cryst Eng Comm,2012,14(5):1554-1560.
- [17]Lei M,Tang W H,Cao L Z,et al.Effects of poly(sodium 4-styrene-sulfonate)on morphology of calcium carbonate particles[J].J Cryst Growth,2006,294(2):358-366.
- [18]Tong W J,Dong W F,Gao C Y,et al.Charge-controlled permeability of polyelectrolyte microcapsules[J].J Phys Chem B,2005,109(27):13159-13165.
- [19]Wei W,Ma G H,Yu D,et al.Preparation of hierarchical hollow Ca CO3 particles and the application as anticancer drug carrier[J].J Am Chem Soc,2008,130(47):15808-15810.