维生素A醋酸酯微胶囊化的制备工艺研究Preparation of vitamin A acetate microcapsules and process optimization
石立芳,刘香,周沫霖,张其磊
摘要(Abstract):
研究了原料配方、乳化工艺条件及喷雾干燥操作参数对维生素A醋酸酯微胶囊产品性能的影响。通过实验设计得到优化乳化工艺条件为:壁材(明胶)与芯材(VA油)的最佳质量比为4:1,乳化的最佳温度为60℃,乳化液pH 4.5,乳化时间40 min,乳化剪切速度10 000 r×min~(-1)。最佳的喷雾干燥条件为进风温度120~140℃,进料流量20 mL×min~(-1),乳液固含量25%~30%。同时,对维生素A醋酸酯微胶囊外观、包埋度、含水量和储存稳定性等进行了表征。
关键词(KeyWords): 维生素A;乳化液;微胶囊;喷雾干燥
基金项目(Foundation):
作者(Author): 石立芳,刘香,周沫霖,张其磊
参考文献(References):
- [1]张峻,齐崴,韩志慧.食品微胶囊、超微粉碎加工技术[M].北京:化学工业出版社,2005ZHANG J,QI W,HAN Z H.Food microencapsulation and superfine grinding[M].Beijing:Chemical Industry Press,2005.
- [2]孙平.食品添加剂使用手册[M].北京:化学工业出版社,2004.SUN P.Handbook of food additives[M].Beijing:Chemical Industry Press,2004.
- [3]刘永霞,于才渊,王晓光.油田堵漏剂微胶囊技术的研究[J].高校化学工程学报.2003,17(3):344-348.LIU Y X,YU C Y,WANG X G.Study on microcapsulation technology of the lost circulation material for the oil field[J].Journal of Chemical Engineering of Chinese Universities,2003,17(3):344-348.
- [4]倪沛红,张明组,陈漫里,等.用微胶囊萃取铀[J].高校化学工程学报,1997,11(3):323-326.NI P H,ZHANG M Z,CHEN M L,et al.Extraction of uranyl ions with polyuria microcapsules[J].Journal of Chemical Engineering of Chinese Universities,1997,11(3):323-326.
- [5]于才渊,姚辉,金希江,等.磷脂微胶囊制备方法研究[J].高校化学工程学报,2004,18(6):733-738.YU C Y,YAO H,JIN X J,et al.The preparation method and technology of phospholipid microencapsulation[J].Journal of Chemical Engineering of Chinese Universities,2004,18(6):733-738.
- [6]上海医药工业研究院制剂研究室.维生素A微型胶囊的研究I:维生素A包囊工艺[J].药物研究与临床试验,1976(4):8-10.Shanghai Institute of Pharmaceutical Industry.Research on VA microcapsules I:Encapsulation process[J].Drug Research and Clinicals,1976(4):8-10.
- [7]上海医药工业研究院制剂研究室.维生素A微型胶囊的研究II:多种维生素片中为维生素A微囊的研究[J].药物研究与临床试验,1976(5):4-10.Shanghai Institute of Pharmaceutical Industry.Research on VA microcapsules II:VA microcapsules in multi-vitamin tablets[J].Drug Research and Clinicals,1976(5):4-10.
- [8]上海医药工业研究院制剂研究室.维生素A微型胶囊的研究III:以桃胶代替阿拉伯胶作包囊材料[J].药物研究与临床试验,1977(3):11-22.Shanghai Institute of Pharmaceutical Industry.Research on VA microcapsules III:Replace of peach gum with Arabic gum[J].Drug research and clinicals,1977(3):11-22..
- [9]侯惠民,左琏光,张兰玲.流动床喷雾造粒法制备维生素A包衣颗粒[J].医学通报,1980,15(7):15-16.HOU H M,ZUO L G,ZHANG L L.Preparation of VA particles by spray drying using fluidized beds[J].Chinese Pharmaceutical Journal,1980,15(7):15-16.
- [10]洪毅敏,张莉华,刘爱琴.维生素A醋酸酯微胶囊的制备及性质研究[J].中国食品添加剂,2010(3):99-102.HONG Y M,ZHANG L H,LIU A Q.Preparation and properties of vitamin A acetate microcapsules[J].China Food Additive,2010(3):99-102.
- [11]王华,王泽南,赵晓光.维生素A微胶囊化工艺的研究[J].食品科学,2010,27(11):366-368.WANG H,WANG Z N,ZHAO X G.Study on technology of vitamin A microencapsulation[J].Food Science.2010,27(11):366-368.
- [12]谢岩黎,周惠明,钱海峰.模糊数学在维生素A微胶囊工艺参数优化中的应用[J].食品与生物技术学报,2006,25(6):29-33.XIE Y L,ZHOU H M,QIAN H F.Study of fully mathematics in optimization for the technics parameter of vitamin A microcapsule[J].Journal of Food Science and Biotechnology,2006,25(6):29-33.
- [13]刘爱琴,罗超杰,周迪.满意度函数法对维生素A微胶囊的多目标优化[J].食品研究与开发,2014,35(8):46-50.LIU A Q,LUO C J,ZHOU D.Multiple target optimization on vitamin A microencapsulation by desirability function approach[J].Food Research And Development,2014,35(8):46-50.
- [14]PICA K,TCHAD R,OFNER C M.Gelatin-methotrexate conjugate microspheres as a potential drug delivery system[J].Journal of Pharmaceutical Sciences,2006,95(9):1896-1908.
- [15]TSUNG M,BURGESS D J.Preparation and stabilization of heparin/gelatin complex coacervate microcapsules[J].Journal of Pharmaceutical Sciences,1997,86(5):603-607.
- [16]黄英雄,孙红明,华聘聘.微胶囊化粉末油脂制品表面油测定方法的研究[J].中国油脂,2002,27(4):61-63.HUANG Y X,SUN H M,HUA P P.Research on the methods of determining the surface oil of microencapsulated powdered oil[J].China Oils And Fats,2002,27(4):61-63.
- [17]陈鑫,郑柏存,沈军.喷雾干燥条件对VAE聚合物分体粒径影响[J].高校化学工程学报,2013,27(3):538-541.CHEN X,ZHENG B C,SHEN J.Effects of spray frying conditions on particle sizes of VAE polymer powders[J].Journal of Chemical Engineering of Chinese Universities,2013,27(3):538-541.
- [18]盛江峰,马淳安,张诚,等.喷雾干燥法制备偏钨酸铵微球时的形貌与粒度[J].高校化学工程学报,2008,22(1):122-127.SHENG J F,MA C A,ZHANG C,et al.Morphology and size of ammonium metatungstate microsphere prepared by spray drying method[J].Journal of Chemical Engineering of Chinese Universities,2008,22(1):122-127.
- [19]吴克刚,柴向华.单细胞AA油喷雾干燥微胶囊化壁材包埋性能的研究[J].高校化学工程学报,2008,22(5):797-802.WU K G,CHAI X H.Performance of various shell materials for microencapsulation of single cell oil rich in arachidonic acid by spray drying[J].Journal of Chemical Engineering of Chinese Universities,2008,22(5):797-802.
- [20]郭宜祜,王喜忠.喷雾干燥[M].北京:化学工业出版社,1983.GUO Y H,WANG X Z.Spray drying[M].Beijing:Chemical Industry Press,1983.